Practical Aspects of Population Pharmacokinetics & Pharmacodynamics

Population pharmacokinetics and pharmacodynamics of pyronaridine

ii To my dad, my mom, and my sister. For their unconditional love, care, support, and encouragement. iii It is not the fruits of scientific research that elevate man and enrich his nature, but the urge to understand, the intellectual work, creative or receptive. Albert Einstein Ideas and Opinions, 1954 iv ACKNOWLEDGMENTS This thesis would not have been possible without the help and support of a...

Aspects of pharmacokinetics and pharmacodynamics of sufentanil in pediatric practice.

Sufentanil is a potent synthetic opioid. Like other opioids, sufentanil creates a stable hemodynamic environment in cardiovascularly compromised pediatric patients. Clearance, expressed as per kilogram, is increased in children compared to adults. The P450 CYP3A4 enzyme is responsible for the major metabolic N-dealkylation pathway. Enzyme activity is reduced in neonates but the maturation of su...

Pharmacokinetics/ Pharmacodynamics

Population pharmacokinetics/pharmacodynamics relationships of an anticancer drug.

This paper proposes a method for studying the toxicity of an anticancer drug with a delayed effect. The goal is to predict a dosage regimen with controlled toxicity. To this end, a semi-physiological model is used. A limit of toxicity is demonstrated, which is intrinsic to the model. It reduces the effect of high drug concentrations. This limit explains the mixed behaviour of the drug: time-dep...

Population pharmacokinetics and pharmacodynamics of cysteamine in nephropathic cystinosis patients

BACKGROUND Nephropathic cystinosis is an autosomal recessive disorder resulting in an impaired transport of cystine trough the lysosomal membrane causing an accumulation of free cystine in lysosomes. The only specific treatment for nephropathic cystinosis is cysteamine bitartrate. This study was aimed to describe the relationship between cysteamine plasma concentrations and white blood cell cys...